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KMID : 1059520140580020153
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Journal of the Korean Chemical Society
2014 Volume.58 No. 2 p.153 ~ p.159
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Cyclic Voltammetric Investigation of Interactions between Bisnitroaromatic Compounds and ds.DNA
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Janjua Naveed Kausar
Akhter Zareen
Jabeen Fariya
Iftikhar Bushra
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Abstract
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Herein, the cyclic voltammetric (CV) investigations of structurally similar bisnitrocompounds (N3, N4, N5, N6, having different -CH2- spacer length) is presented. CV study offered interesting interactional possibilities of bisnitrocompounds with chicken blood ds.DNA at physiological pH 4.7 and human body temperature, 310 K. The results indicated strong interaction by these symmetric molecules with ds.DNA and strength of binding is found to depend on length of CH2 spacer group in their molecular structure. Thermodynamics derived from electrochemical binding parameters also favored the irreversible interactions. Moreover, threading intercalation mode of binding is suggested based on thermodynamic and kinetic binding parameters extracted from CV studies.
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KEYWORD
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Bisnitrocompounds, ds.DNA binding, Cyclic voltammetry, Threading intercalation
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